The main problem I see is that you wind up with a fairly long distance between the front of the motor and the axle centerline. But bike engines are shorter and less bulky on top than car engines, which would let you tuck it into the firewall a bit more.
On the other hand, it's probably still shorter than a chain drive diff behind the engine, not to mention the forward lean of most modern sportbike engines is the opposite direction from the firewall.
The Audi diff is both bulky and heavy, but it'd be bulletproof, and there's a decent assortment of gears and final drives available for it. There have been lighter and smaller transaxles, but most of them are old, oddball, designed for engines with much less power, and not much in the way of gear ratio options.
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